Generic Duloxetine is an inexpensive analog of Cymbalta, which made a good showing during treatment of moderate depression. It is used as a basic or auxiliary means for depression and neuropathic pain treatment. This substance provides balanced stimulating and calming effects without causing excessive drowsiness and psychoactivity.

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Key facts about Duloxetine

  • Solid dose form – sustained release capsules.
  • Belongs to the SSNRI drug class.
  • Brand name – Cymbalta.
  • Helps improve the lives of people with mental disorders.

Duloxetine improves symptoms of depression during the first 15 days. It may take up to 30 days before you feel better.

What Duloxetine does and what it is used for?

Duloxetine regulates the amount of naturally occurring substances in the brain (neurotransmitters) that work on mood and emotions.

The antidepressant Duloxetine may be effective in treating a number of conditions, such as:

  • Clinical depression
  • Neuropathic pain in diabetes
  • Generalized anxiety disorder


Recommended oral doses

Unlike many other antidepressants, Duloxetine can be taken any time of the day. It is better to choose fixed time for dosing, which will ensure a better effect of the medication and a lower chance of you forgetting about the next dose.

You start with a low dose (30-60 mg). The dose is gradually increased to the one that is right for you.

  • Usual therapeutic dose for most patients: 60 mg once daily.
  • Maximum dose for depression: 120 mg daily.
  • The daily dose can be divided into 2 doses.

The capsules should be swallowed whole without chewing or crushing. Do not add the drug to food and do not mix it with liquids, as this can damage the enteric capsule shell.

After symptoms improve, you should continue using the drug for six months or more. It reduces the likelihood of later recurrence of depressive episodes.

Are there any risks of adverse reactions?

Although the antidepressant effect manifests only in a few weeks, you may experience side effects immediately after you the treatment initiation. Do not stop treatment, because side effects usually improve or disappear as the body gets used to the drug action.

Possible side effects:

  • Loss of water from the body
  • Feeling thirsty
  • Difficulty falling asleep
  • Early awakening
  • Yellowing of the skin
  • Decreased blood sodium concentration
  • Difficulty urinating
  • Increased muscle tone
  • Feeling of general discomfort

The severity of side effects ranges from mild to moderate. Be sure to talk to your doctor or pharmacist if any of the side effects persist over an extended period.

If you have allergy symptoms or feel chest tightness or pain, consult with your doctor.

Additional information

Do not start taking the medicine in the following situations:

  • Treatment with MAOIs
  • Severe kidney disease
  • Abnormal liver function
  • Uncontrolled arterial hypertension
  • Hypersensitivity to the drug

Alcohol and central-acting agents can increase the sedative effect of Duloxetine.

Driving during the use of this medication (especially in the first week) can be dangerous. Do not drive if you experience drowsiness, blurred vision, or loss of concentration.